Authors:
Egbunefu, Chukwudi Omeni ,
Iyama, William Azuka and Taylor, Soye Phin ,Nigeria
|
Abstract:
The safety Assessment of anti-diarrhoeal activity of methanol extract of J.curcasleaf at different
dose levels on castor-oil induced diarrhoea in albino rats was carried out. Thirty (30) albino rats
were divided into 5 groups of 6 rats each. Three groups of the albino rats were administered with
3 different doses of the extracts and the fourth and fifth groups received diphenyloxylate
(5mg/kg bdy wt.) and 0.5% v/v aqueous tween 80(1ml) orally respectively. Sixty (60)minutes
after the drug treatment each animal was administered with 1ml of castor-oil orally and observed
for defecation for about four hours. The animals were sacrificed and the effect of the leaf extract
on biochemistry and Histopathological examination of the kidney and liver tissues were assessed
using standard techniques. The results showed that, there was no significant difference(P>0.05)
in the biochemical parameters: total protein, albumin, globulin, alanine amino transferase (ALT)
and Aspartate Amino transferase (AST), between the experimental animals and the control.
Histopathological assessment of the liver and kidney tissues showed mild alterations of the
histological features. The findings of this study showed that the leaf extract of J. curcas has no
adverse effect on the experimental animals |
