This study paper explores socio-demographic variables predicting HIV/AIDS preventive measures among the senior secondary school students in Edo State. Specifically, the study sought to determine the ascertain if demographic variables of sex, age, predict HIV/AIDS preventive measures (abstinence, condom use and voluntary counselling/testing) among the senior secondary school students in Edo State. The design of study was the correlational research design. Population of the study consisted of all the senior secondary school students in Edo State. The sample of the study comprised of nine hundred and thirty-seven (937) students in the senior secondary schools in Edo State. This represented one percent (1%) of the population of the study. The research instrument that was used to gather data for the study was a questionnaire. Hypothesis was tested using logistic regressions analysis. The logistic regression analysis was used to show if demographic variables (sex, age) significantly predict HIV/AIDS preventive measures among senior secondary students in Edo State. The result showed that age was the main predictors of the HIV/AIDS of preventive measures among senior secondary school students in Edo state. It was therefore recommended that Government at all levels should put policies in place to provide free HIV voluntary counselling for students in Edo State.