The main objective of this study is to contribute to the knowledge of the species of the Euphorbiaceae family from Côte d’Ivoire. Specifically, this involves carrying out a floristic analysis of Euphorbiaceae from Côte d’Ivoire, determining the species with special statuses of the Euphorbiaceae family from Côte d’Ivoireand analyzing their potential distribution. The endangered species database (Aké Assi, 1988) and the IUCN Red List (2019) were used to identify species with special status. Quantum GIS software and the Maxent model were used for the realization of the potential distribution maps. Four special status species have been listed: Croton membranaceusMüll. Arg., Croton aubrevillei J. Léonard et Macaranga beillei Pan. And Sapiumcaterinum J. Léonard. The potential distribution map of Sapiumcaterinum J. Léonard, was not produced due to insufficient number of samples. Floristic analysis revealed that 75% of species are microphanerophytes, 50% are endemic to the forest block west of Togo, including Ghana, Ivory Coast, Liberia, Sierra Leone, Guinea Bissau, Gambia and Senegal.